Design and evaluation of nasal delivery of Metoclopramide hydrochloride Microspheres
نویسندگان
چکیده
منابع مشابه
Freeze-dried Xanthan/Guar Gum Nasal Inserts for the Delivery of Metoclopramide Hydrochloride
Prolonged residence of drug formulation in the nasal cavity is important for the enhancing intranasal drug delivery. The objective of the present study was to develop a mucoadhesive in-situ gelling nasal insert which would enable the reduced nasal mucociliary clearance in order to improve the bioavailability of metoclopramide hydrochloride. Metoclopramide hydrochloride is a potent antiemetic...
متن کاملFreeze-dried Xanthan/Guar Gum Nasal Inserts for the Delivery of Metoclopramide Hydrochloride
Prolonged residence of drug formulation in the nasal cavity is important for the enhancing intranasal drug delivery. The objective of the present study was to develop a mucoadhesive in-situ gelling nasal insert which would enable the reduced nasal mucociliary clearance in order to improve the bioavailability of metoclopramide hydrochloride. Metoclopramide hydrochloride is a potent antiemetic...
متن کاملMucoadhesive Microspheres of Propranolol Hydrochloride for Nasal Delivery
Gelatin A microspheres of propranolol hydrochloride for intranasal systemic delivery were developed with the aim to avoid fi rst pass metabolism, to improve the patient compliance, to use an alternative therapy to conventional dosage form, to achieve controlled blood level profi les, and to improve the therapeutic effi cacy of propranolol hydrochloride in the treatment of various cardiovascular...
متن کاملFormulation and Evaluation of Mucoadhesive Microspheres for Intra -nasal Delivery
Intranasal administration is an ideal alternative to the parenteral route for systemic drug delivery. Various conventional dosage forms have been employed for this purpose but they lack to provide the desired bioavailability of the drug due to poor residence time and faster clearance in the nasal cavity. Formulating multiparticulate system with mucoadhesive polymers may provide a significant in...
متن کاملFreeze-dried Xanthan/Guar Gum Nasal Inserts for the Delivery of Metoclopramide Hydrochloride
Prolonged residence of drug formulation in the nasal cavity is important for the enhancing intranasal drug delivery. The objective of the present study was to develop a mucoadhesive in-situ gelling nasal insert which would enable the reduced nasal mucociliary clearance in order to improve the bioavailability of metoclopramide hydrochloride. Metoclopramide hydrochloride is a potent antiemetic an...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmacy and Pharmacology
سال: 2018
ISSN: 2455-2674
DOI: 10.31024/ajpp.2018.4.3.18